Illuminating synapses and circuitry in the retina

In the central nervous system, space is at a premium. This is especially true in the retina, where synapses, cells, and circuitry have evolved to maximize signal-processing capacity within a thin, optically transparent tissue. For example, at some retinal synapses, single presynaptic active zones contact multiple postsynaptic targets; some individual neurons perform completely different tasks depending on visual conditions, while others execute hundreds of circuit computations in parallel; and the retinal network adapts, at various levels, to the ever-changing visual world. Each of these features reflects efficient use of limited cellular resources to optimally encode visual information.

Research highlights► Receptor diversity encodes multiple information channels. ► Individual neurons perform different tasks within the retinal network. ► Local microcircuits enable parallel processing within single cells. ► Retinal synapses adapt to operate over a broad visual range.