Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels

► FXS is a common form of mental disability and one of the known causes of autism. ► Targeted treatments of FXS based on the mGluR theory is a feasible therapeutic strategy. ► It is also important to extend our understanding of FMRP functions beyond mGluR signaling. ► Several potassium channels show alterations in mouse models of FXS. ► We suggest possible therapeutic avenues for treating FXS regarding the role of potassium channels.