Homeostatic synaptic plasticity: from single synapses to neural circuits

► Homeostatic plasticity tunes presynaptic and postsynaptic strengths to altered activity. ► Matching of presynaptic and postsynaptic strengths uses dendritic retrograde signals. ► Global and local homeostatic synaptic plasticities are likely to operate in parallel. ► Heterosynaptic interactions may help co-ordinate Hebbian and homeostatic changes.