Clinical NeuroscienceEEG source localization: Sensor density and head surface coverage

- Sensors on inferior surface improve localization accuracy for deep sources.
- Sensors on inferior surface reduce error variability of sources at all depths.
- Sensors on inferior surface improve localization accuracy even with sparse arrays.
- Most accurate source localization is obtained with whole-head, dense-array sampling.

BackgroundThe accuracy of EEG source localization depends on a sufficient sampling of the surface potential field, an accurate conducting volume estimation (head model), and a suitable and well-understood inverse technique. The goal of the present study is to examine the effect of sampling density and coverage on the ability to accurately localize sources, using common linear inverse weight techniques, at different depths. Several inverse methods are examined, using the popular head conductivity.New methodSimulation studies were employed to examine the effect of spatial sampling of the potential field at the head surface, in terms of sensor density and coverage of the inferior and superior head regions. In addition, the effects of sensor density and coverage are investigated in the source localization of epileptiform EEG.ResultsGreater sensor density improves source localization accuracy. Moreover, across all sampling density and inverse methods, adding samples on the inferior surface improves the accuracy of source estimates at all depths.Comparison with existing methodsMore accurate source localization of EEG data can be achieved with high spatial sampling of the head surface electrodes.ConclusionsThe most accurate source localization is obtained when the voltage surface is densely sampled over both the superior and inferior surfaces.