Computational neuroscienceICA of full complex-valued fMRI data using phase information of spatial maps

- ICA of the full complex-valued fMRI data is enabled.
- The SM phases are utilized to identify and suppress the unwanted voxels.
- Our TC-based phase de-ambiguity is more accurate and robust than the SM-based method.
- The phase range of BOLD-related voxels is defined by maximizing TC real-part power.
- Our method can detect much more contiguous activations than magnitude-only ICA.

BackgroundICA of complex-valued fMRI data is challenging because of the ambiguous and noisy nature of the phase. A typical solution is to remove noisy regions from fMRI data prior to ICA. However, it may be more optimal to carry out ICA of full complex-valued fMRI data, since any filtering or voxel-based processing may disrupt information that can be useful to ICA.New methodWe enable ICA of the full complex-valued fMRI data by utilizing phase information of estimated spatial maps (SMs). The SM phases are first adjusted to properly represent spatial phase changes of all voxels based on estimated time courses (TCs), and then these are used to segment the voxels into BOLD-related and unwanted voxels based on a criterion of TC real-part power maximization. Single-subject and group phase masks are finally constructed to remove the unwanted voxels from the individual and group SM estimates.ResultsOur method efficiently estimated not only the task-related component but also the non-task-related component DMN.Comparison with existing method(s)Our method extracted 139-331% more contiguous and reasonable activations than magnitude-only infomax for the task-related component and DMN at |Z| > 2.5, and detected more BOLD-related voxels, but eliminated more unwanted voxels than ICA of complex-valued fMRI data with pre-ICA de-noising. Our TC-based phase de-ambiguity exhibited higher accuracy and robustness than the SM-based method.ConclusionsThe TC-based phase de-ambiguity is essential to prepare the SM phases. The SM phases provide a new post-ICA index for reliably identifying and suppressing the unwanted voxels.