کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6268306 1614625 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical NeuroscienceA system and method to interface with multiple groups of axons in several fascicles of peripheral nerves
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Clinical NeuroscienceA system and method to interface with multiple groups of axons in several fascicles of peripheral nerves
چکیده انگلیسی


- Developed a distributed intrafascicular multi-electrode for neural interfacing.
- Developed multi-electrode multi-lead packaging processes.
- Developed surgical procedures to implant the distributed multi-electrode.
- Tested surgical procedures in a cadaver arm.

BackgroundSeveral neural interface technologies that stimulate and/or record from groups of axons have been developed. The longitudinal intrafascicular electrode (LIFE) is a fine wire that can provide access to a discrete population of axons within a peripheral nerve fascicle. Some applications require, or would benefit greatly from, technology that could provide access to multiple discrete sites in several fascicles.New methodThe distributed intrafascicular multi-electrode (DIME) lead was developed to deploy multiple LIFEs to several fascicles. It consists of several (e.g. six) LIFEs that are coiled and placed in a sheath for strength and durability, with a portion left uncoiled to allow insertion at distinct sites. We have also developed a multi-lead multi-electrode (MLME) management system that includes a set of sheaths and procedures for fabrication and deployment.ResultsA prototype with 3 DIME leads was fabricated and tested in a procedure in a cadaver arm. The leads were successfully routed through skin and connective tissue and the deployment procedures were utilized to insert the LIFEs into fascicles of two nerves.Comparison with existing method(s)Most multi-electrode systems use a single-lead, multi-electrode design. For some applications, this design may be limited by the bulk of the multi-contact array and/or by the spatial distribution of the electrodes.ConclusionWe have designed a system that can be used to access multiple sets of discrete groups of fibers that are spatially distributed in one or more fascicles of peripheral nerves. This system may be useful for neural-enabled prostheses or other applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 244, 15 April 2015, Pages 78-84
نویسندگان
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