Computational NeuroscienceLinkRbrain: Multi-scale data integrator of the brain

- The linkRbrain platform cumulates information from several open databases.
- It integrates these multi-scale data into a common framework.
- It systematically links a set of brain coordinates to a set of cognitive labels.
- It systematically link a genetic expression profile to a set of cognitive labels.
- Based on the topographical overlap, the linkRbrain provides relational graphs.

BackgroundLinkRbrain is an open-access web platform for multi-scale data integration and visualization of human brain data. This platform integrates anatomical, functional, and genetic knowledge produced by the scientific community.New methodThe linkRbrain platform has two major components: (1) a data aggregation component that integrates multiple open databases into a single platform with a unified representation; and (2) a website that provides fast multi-scale integration and visualization of these data and makes the results immediately available.ResultsLinkRbrain allows users to visualize functional networks or/and genetic expression over a standard brain template (MNI152). Interrelationships between these components based on topographical overlap are displayed using relational graphs. Moreover, linkRbrain enables comparison of new experimental results with previous published works.Comparison with existing methodsPrevious tools and studies illustrate the opportunities of data mining across multiple tiers of neuroscience and genetic information. However, a global systematic approach is still missing to gather cognitive, topographical, and genetic knowledge in a common framework in order to facilitate their visualization, comparison, and integration.ConclusionsLinkRbrain is an efficient open-access tool that affords an integrative understanding of human brain function.