کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6268391 1614627 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Computational NeuroscienceShort communicationModified Richardson's method versus the box-counting method in neuroscience
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Computational NeuroscienceShort communicationModified Richardson's method versus the box-counting method in neuroscience
چکیده انگلیسی


- Lewis Fry Richardson was a Quaker and physicist.
- Richardson's method measures the fractal dimensions of open and closed lines.
- The fractal dimension of neuronal arborization can be measured by this method.
- Modified Richardson's method gives more precise results than box-counting method.

BackgroundThe morphology of dendrites, including apical dendrites of pyramidal neurons, is already well-known. However, the quantification of their complexity still remains open. Fractal analysis has proven to be a valuable method of analyzing the degree of complexity of dendrite morphology.New methodRichardson's method is a technique of measuring the fractal dimension of open and closed lines of objects. This method was modified in order to measure the fractal dimension of neuronal arborization. The focus of this experiment was on the apical dendrites of superficial and deep pyramidal neurons in the rat cerebral cortex.ResultsApical dendrites of superficial cortical pyramidal neurons have a higher mean value of the fractal dimension as compared to deep pyramidal neurons.Comparison with existing methodUsing the modified Richardson's method we showed that the mean value of the fractal dimension of apical dendrites in superficial pyramidal neurons is highly statistically significant as compared to the value of the fractal dimension in deep pyramidal neurons. On the other hand, the mean values of the fractal dimension between the same groups of apical dendrites measured by the most popular box-counting method showed merely a statistically significant difference.ConclusionThe modified Richardson's method of fractal analysis is an efficient mathematical method for calculating the fractal dimension of dendrites and could be used in order to calculate the complexity of dendrite arborization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 242, 15 March 2015, Pages 93-96
نویسندگان
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