کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6268978 1295111 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Basic NeuroscienceAn inexpensive, charge-balanced rodent deep brain stimulation device: A step-by-step guide to its procurement and construction
ترجمه فارسی عنوان
عصبشناسی پایه: دستگاه تحریک مغزی عمیق مغز جوندگان ارزان قیمت، تعادل شارژ: یک راهنمای گام به گام برای تهیه و ساخت آن
کلمات کلیدی
تحریک مغزی عمیق، جوندگان قابل برنامه ریزی مزمن، دو طرفه، تعادل شارژ،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- The device has an extremely long lifetime with typical stimulation parameters.
- The device is initially fully programmable in frequency, pulse-width and current amplitude allowing the study of any common stimulation paradigm.
- Two independent outputs are charge-balanced ensuring zero net current delivery per period.
- The device is inexpensive and easy to replicate.

BackgroundDespite there being a relatively large number of methods papers which detail specifically the development of stimulation devices, only a small number of reports involve the application of these devices in freely moving animals. To date multiple preclinical neural stimulators have been designed and described but have failed to make an impact on the methods employed by the majority of laboratories studying DBS. Thus, the overwhelming majority of DBS studies are still performed by tethering the subject to an external stimulator. We believe that the low adoption rate of previously described methods is a result of the complexity of replicating and implementing these methods.New methodHere were describe both the design and procurement of a simple and inexpensive stimulator designed to be compatible with commonly used, commercially available electrodes (Plastics 1).ResultsThis system is initially programmable in frequency, pulsewidth and current amplitude, and delivers biphasic, charge-balanced output to two independent electrodes.Comparison with existing method(s)It is easy to implement requiring neither subcutaneous implantation nor custom-made electrodes and has been optimized for either direct mounting to the head or for use with rodent jackets.ConclusionsThis device is inexpensive and universally accessible, facilitating high throughput, low cost, long-term rodent deep brain stimulation experiments.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 219, Issue 2, 15 October 2013, Pages 324-330
نویسندگان
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