کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6269017 | 1295113 | 2013 | 8 صفحه PDF | دانلود رایگان |
Here we report the establishment of a novel spatial learning and memory test called the cold radial maze. It is specifically designed for mice, with all conditions tailored to their natural behaviors. The cold radial maze is a dry-land test with easy-to-measure variables that relies on a consistent motivation system and limits the moderately adverse experience to the duration of testing. Training on this maze produces a long-lasting, resistant, and reversible spatial memory in mice in a reproducible way, without introducing undesirable side effects typically produced in other spatial learning tests. This novel behavioral technique may prove useful in studying mouse models of memory impairment-associated human conditions.
⺠We developed a novel spatial learning test for mice, the cold radial maze. ⺠It is ethologically relevant and limits adverse experience to the time of testing. ⺠Its cold surface warrants strong and consistent motivation in mice. ⺠We show that learning on the new task is gradual, reproducible and reversible. ⺠Training on the cold radial maze produces a long-lasting and resistant memory.
Journal: Journal of Neuroscience Methods - Volume 213, Issue 2, 15 March 2013, Pages 274-281