کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6269017 1295113 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Basic NeuroscienceA cold radial maze for long-lasting spatial memory in mice
ترجمه فارسی عنوان
عصب شناسی عمومی عصب رادیویی سرد برای حافظه فضایی طولانی مدت در موش
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی

Here we report the establishment of a novel spatial learning and memory test called the cold radial maze. It is specifically designed for mice, with all conditions tailored to their natural behaviors. The cold radial maze is a dry-land test with easy-to-measure variables that relies on a consistent motivation system and limits the moderately adverse experience to the duration of testing. Training on this maze produces a long-lasting, resistant, and reversible spatial memory in mice in a reproducible way, without introducing undesirable side effects typically produced in other spatial learning tests. This novel behavioral technique may prove useful in studying mouse models of memory impairment-associated human conditions.

► We developed a novel spatial learning test for mice, the cold radial maze. ► It is ethologically relevant and limits adverse experience to the time of testing. ► Its cold surface warrants strong and consistent motivation in mice. ► We show that learning on the new task is gradual, reproducible and reversible. ► Training on the cold radial maze produces a long-lasting and resistant memory.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 213, Issue 2, 15 March 2013, Pages 274-281
نویسندگان
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