کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6269136 1295122 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fluctuations in the open time of synaptic channels: An application to noise analysis based on charge
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Fluctuations in the open time of synaptic channels: An application to noise analysis based on charge
چکیده انگلیسی

Synaptic channels are stochastic devices. Even recording from large ensembles of channels, the fluctuations, described by Markov transition matrices, can be used to extract single channel properties. Here we study fluctuations in the open time of channels, which is proportional to the charge flowing through the channel. We use the results to implement a novel type of noise analysis that uses the charge rather than the current to extract fundamental channel parameters. We show in simulations that this charge based noise analysis is more robust if the synapse is located on the dendrites and thus subject to cable filtering. However, we also demonstrate that when multiple synapses are distributed on the dendrites, noise analysis breaks down. We finally discuss applications of our results to other biological processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 210, Issue 1, 15 September 2012, Pages 15-21
نویسندگان
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