کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6269390 1295136 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Computational NeuroscienceEvidence-based modeling of network discharge dynamics during periodic pacing to control epileptiform activity
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Computational NeuroscienceEvidence-based modeling of network discharge dynamics during periodic pacing to control epileptiform activity
چکیده انگلیسی

Deep brain stimulation (DBS) is a promising therapeutic approach for epilepsy treatment. Recently, research has focused on the implementation of stimulation protocols that would adapt to the patients need (adaptive stimulation) and deliver electrical stimuli only when it is most useful. A formal mathematical description of the effects of electrical stimulation on neuronal networks is a prerequisite for the development of adaptive DBS algorithms. Using tools from non-linear dynamic analysis, we describe an evidence-based, mathematical modeling approach that (1) accurately simulates epileptiform activity at time-scales of single and multiple ictal discharges, (2) simulates modulation of neural dynamics during epileptiform activity in response to fixed, low-frequency electrical stimulation, (3) defines a mapping from real-world observations to model state, and (4) defines a mapping from model state to real-world observations. We validate the real-world utility of the model's properties by statistical comparison between the number, duration, and interval of ictal-like discharges observed in vitro and those simulated in silica under conditions of repeated stimuli at fixed-frequency. These validation results confirm that the evidence-based modeling approach captures robust, informative features of neural network dynamics of in vitro epileptiform activity under periodic pacing and support its use for further implementation of adaptive DBS protocols for epilepsy treatment.

► We model in vitro epileptiform activity under fixed-frequency stimulation. ► The model simulates modulation of epileptiform activity in response to stimulation. ► The model defines an invertible mapping between observations and numerical state. ► The model may serve as a predictor, simulation, or as part of a control system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 204, Issue 2, 15 March 2012, Pages 318-325
نویسندگان
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