Estimation of the time course of neurotransmitter release at central synapses from the first latency of postsynaptic currents

► Method for estimating vesicular release time course from PSC first latencies. ► Analytical derivation of binomial model of release at central synapses. ► Systematic tests of robustness with biologically realistic simulations. ► Generalization of existing first latency correction based on Poisson model.