کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6269660 | 1295149 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Short communicationTwo pitfalls of BOLD fMRI magnitude-based neuroimage analysis: Non-negativity and edge effect Short communicationTwo pitfalls of BOLD fMRI magnitude-based neuroimage analysis: Non-negativity and edge effect](/preview/png/6269660.png)
BOLD fMRI is accepted as a noninvasive imaging modality for neuroimaging and brain mapping. A BOLD fMRI dataset consists of magnitude and phase components. Currently, only the magnitude is used for neuroimage analysis. In this paper, we show that the fMRI-magnitude-based neuroimage analysis may suffer two pitfalls: one is that the magnitude is non-negative and cannot differentiate positive from negative BOLD activity; the other is an edge effect that may manifest as an edge enhancement or a spatial interior dip artifact at a local uniform BOLD region. We demonstrate these pitfalls via numeric simulations using a BOLD fMRI model and also via a phantom experiment. We also propose a solution by making use of the fMRI phase image, the counterpart of the fMRI magnitude.
Journal: Journal of Neuroscience Methods - Volume 199, Issue 2, 15 August 2011, Pages 363-369