کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6269671 | 1295153 | 2011 | 10 صفحه PDF | دانلود رایگان |

In moderate to severely impaired stroke patients, single pulse TMS, with or without background facilitation, may not be able to evoke a motor response in muscles of the upper extremity, thereby hindering potential studies of stroke patients using TMS. Paired pulse TMS has been shown to facilitate responses in distal muscles of healthy subjects. In this study, our aim was to investigate thirteen muscles of the upper extremity in moderate to severely impaired stroke patients and determine the paired pulse interstimulus interval (ISI) that was optimal for facilitation of the TMS response.MethodsWe recruited 8 moderate to severely impaired stroke patients and 5 healthy controls. A hotspot was found that could activate the greatest number of the 13 target upper extremity muscles. 16 ISIs were tested.ResultsIn healthy controls, an ISI range of 3-50Â ms in the left hemisphere and 8-40Â ms in the right hemisphere was optimal for activating the contralateral arm. In the stroke patients, stimulation of the non-lesioned hemisphere at an ISI of 8-50Â ms was optimal for contralateral responses, similar to the control subjects, while stimulation of the lesioned hemisphere had an optimal ISI range of 12-50Â ms. Ipsilateral responses in the paretic limb were frequent and the optimal ISI range was much later than the contralateral responses in stroke or controls occurring at 25-40Â ms.ConclusionIn stroke and control subjects, across muscles and contralateral or ipsilateral pathways, an interstimulus interval of 25-40Â ms was optimal to evoke a TMS response and resulted in the greatest degree of facilitation.
Research highlightsâ¶ Dual pulse TMS significantly increases the occurrence rate and magnitude of MEPs. â¶ The optimal dual pulse TMS ISI for cMEPs in the stroke paretic limb was 12-50Â ms. â¶ The optimal dual pulse TMS ISI for iMEPs in the stroke paretic limb was 25-40Â ms. â¶ The optimal dual pulse TMS ISI was similar for distal and proximal muscles.
Journal: Journal of Neuroscience Methods - Volume 195, Issue 2, 15 February 2011, Pages 151-160