A robust MRI-compatible system to facilitate highly accurate stereotactic administration of therapeutic agents to targets within the brain of a large animal model

▶ Development of a highly accurate and robust method for MRI-guided, stereotactic delivery of catheters into the brain of pigs. ▶ Reliable head immobilisation, acquisition of high-resolution MR images, precise co-registration of MRI and stereotactic spaces to facilitate accurate burr hole-generation and catheter implantation. ▶ Implants were accurately placed into the putamen with a mean Euclidean distance of 0.623 mm (standard deviation of 0.33 mm).