کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6269817 1295161 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison of the efficacy of four viral vectors for transducing hypothalamic magnocellular neurosecretory neurons in the rat supraoptic nucleus
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Comparison of the efficacy of four viral vectors for transducing hypothalamic magnocellular neurosecretory neurons in the rat supraoptic nucleus
چکیده انگلیسی
► Adenovirus, HIV, AAV2 and AAV5 vectors were all able to transduce SON neurons. ► AAV5 and HIV (lentiviral) vectors were evaluated in the SON for the first time. ► The cell tropism, spread and timing of expression varied significantly among vectors. ► AAV2 and AAV5 showed efficient transduction of neurons, but no glial transduction. ► AAV5 transduced MNCs somewhat selectively relative to other hypothalamic neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 197, Issue 2, 30 April 2011, Pages 238-248
نویسندگان
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