کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6269838 1295161 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A framework on surface-based connectivity quantification for the human brain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
A framework on surface-based connectivity quantification for the human brain
چکیده انگلیسی

Quantifying the connectivity between arbitrary surface patches in the human brain cortex can be used in studies on brain function and to characterize clinical diseases involving abnormal connectivity. Cortical regions of human brain in their natural forms can be represented in surface formats. In this paper, we present a framework to quantify connectivity using cortical surface segmentation and labeling from structural magnetic resonance images, tractography from diffusion tensor images, and nonlinear inter-subject registration. For a single subject, the connectivity intensity of any point on the cortical surface is set to unity if the point is connected and zero if it is not connected. The connectivity proportion is defined as the ratio of the total connected surface area to the total area of the surface patch. By nonlinearly registering the connectivity data of a group of normal controls into a template space, a population connectivity metric can be defined as either the average connectivity intensity of a cortical point or the average connectivity proportion of a cortical region. In the template space, a connectivity profile and a connectivity histogram of an arbitrary cortical region of interest can then be derived from these connectivity quantification values. Results from the application of these quantification metrics to a population of schizophrenia patients and normal controls are presented, revealing connectivity signatures of specified cortical regions and detecting connectivity abnormalities.

Research highlights► We present a surface-based connectivity quantification framework. ► It is based on cortical surface labeling and diffusion tensor tractography. ► It quantifies connectivity strength for arbitrary cortical regions. ► It was validated to use these quantifications to detect connectivity abnormality. ► Connectivity abnormality of schizophrenia patients was revealed with the framework.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 197, Issue 2, 30 April 2011, Pages 324-332
نویسندگان
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