Invited reviewTranscriptome profiling in neurodegenerative disease

Changes in gene expression and splicing patterns (that occur prior to the onset and during the progression of complex diseases) have become a major focus of neurodegenerative disease research. These signature patterns of gene expression provide clues about the mechanisms involved in the molecular pathogenesis of neurodegenerative disease and may facilitate the discovery of novel therapeutic drugs. With the development of array technologies and the very recent RNA-seq technique, our understanding of the pathogenesis of neurodegenerative disease is expanding exponentially. Here, we review the technologies involved in gene expression and splicing analysis and the related literature on three common neurodegenerative diseases: Alzheimer's disease, Parkinson's disease and Huntington's disease.

Research highlights▶ Functional diversity is reflected by the brain region-specific transcriptome pattern. ▶ Gene expression profiling provides clues about the molecular pathology of neurodegeneration. ▶ Next-generation sequencing techniques reveal new depths of the brain transcriptome.