کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6270479 | 1614656 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Is it possible to generate cerebral evoked potentials with a mechanical stimulus from the duodenum in rats? Is it possible to generate cerebral evoked potentials with a mechanical stimulus from the duodenum in rats?](/preview/png/6270479.png)
The study aim was to develop a model to generate cerebral evoked potentials (CEPs) by mechanical distention of the duodenum in rats. Twenty Sprague-Dawley rats were anaesthetized and the EEG recorded from the left and right somatosensory cortices (S1L, S1R). A balloon catheter was implanted into the duodenum. A pneumatic device, triggered by data acquisition software, inflated the balloon for 200Â ms every 3Â s to deliver a repeatable noxious stimulus. EEG was recorded for 100Â ms before and 500Â ms after onset of inflation and the response to 512 stimuli averaged to generate a CEP. Two CEPs were generated in each animal and data summed to calculate a single CEP for each channel.Data were excluded when the signal to noise ratio was <2, therefore data are presented from 11 animals. A repeatable CEP was identified in waveforms recorded from S1L. The mean (S.D.) CEP comprised a triphasic waveform (P1, N1, P2) with latencies of 246.0 (24.7), 289.3 (12.8) and 321.5 (13.2)Â ms, respectively. We are the first group to have generated and characterized a CEP following mechanical stimulation of the duodenum. This model can be applied to further elucidate the mechanisms leading to visceral pain perception.
Journal: Journal of Neuroscience Methods - Volume 162, Issues 1â2, 15 May 2007, Pages 215-221