Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions

Overall, our data indicate that PCP activates a wide range of cortical and subcortical brain regions and that a substantial part of this activation is present in GABAergic interneurons in certain regions. This suggests that the psychotomimetic effect of PCP may be mediated via GABAergic interneurons.