کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6270976 | 1614746 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New insights on amygdala: Basomedial amygdala regulates the physiological response to social novelty
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
MPOABLABMABNSTDMHbasolateral amygdala - amygdala basolateralCeA - CEAbasomedial amygdala - آمیگدال بوسومدیالCentral amygdala - آمیگدالای مرکزیγ-aminobutyric acid - اسید γ-آمینوبوتیریکBMI - شاخص توده بدنیHeart rate - ضربان قلبmean arterial pressure - فشار متوسط شریانیbicuculline methiodide - متیکویدید bicucullinemedial preoptic area - منطقه پیشوپتیک مدیاmap - نقشهbed nucleus of stria terminalis - هسته تخت ترمینال striadorsomedial hypothalamus - هیپوتالاموس dorsomedialGABAA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The amygdala has been associated with a variety of functions linked to physiological, behavioral and endocrine responses during emotional situations. This brain region is comprised of multiple sub-nuclei. These sub-nuclei belong to the same structure, but may be involved in different functions, thereby making the study of each sub-nuclei important. Yet, the involvement of the basomedial amygdala (BMA) in the regulation of emotional states has yet to be defined. Therefore, the aim of our study was to investigate the regulatory role of the BMA on the responses evoked during a social novelty model and whether the regulatory role depended on an interaction with the dorsomedial hypothalamus (DMH). Our results showed that the chemical inhibition of the BMA by the microinjection of muscimol (γ-aminobutyric acid (GABAA) agonist) promoted increases in mean arterial pressure (MAP) and heart rate (HR), whereas the chemical inhibition of regions near the BMA did not induce such cardiovascular changes. In contrast, the BMA chemical activation by the bilateral microinjection of bicuculline methiodide (BMI; GABAA antagonist), blocked the increases in MAP and HR observed when an intruder rat was suddenly introduced into the cage of a resident rat, and confined to the small cage for 15 min. Additionally, the increase in HR and MAP induced by BMA inhibition were eliminated by DMH chemical inhibition. Thus, our data reveal that the BMA is under continuous GABAergic influence, and that its hyperactivation can reduce the physiological response induced by a social novelty condition, possibly by inhibiting DMH neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 330, 25 August 2016, Pages 181-190
Journal: Neuroscience - Volume 330, 25 August 2016, Pages 181-190
نویسندگان
Laura Tavares Mesquita, Aline Rezende Abreu, Alessandra Rezende de Abreu, Aline Arlindo de Souza, Sylvana Rendeiro de Noronha, Fernanda Cacilda Silva, Glenda Siqueira Viggiano Campos, Deoclecio Alves Jr, Rodrigo Cunha de Menezes,