کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6271080 1614753 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewAstroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
ReviewAstroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse
چکیده انگلیسی


- CB1 receptors are present on brain astrocytes.
- Astroglial CB1 receptors participate in the activity of the tripartite synapse.
- Astroglial CB1 receptors mediate working memory impairments induced by cannabinoids.

The endocannabinoid system is an important regulator of physiological functions. In the brain, this control is mainly exerted through the type-1-cannabinoid (CB1) receptors. CB1 receptors are abundant at neuron terminals where their stimulation inhibits neurotransmitter release. However, CB1 receptors are also expressed in astrocytes and recent studies showed that astroglial cannabinoid signaling is a key element of the tripartite synapse. In this review we discuss the different mechanisms by which astroglial CB1 receptors control synaptic transmission and plasticity. The recent involvement of astroglial CB1 receptors in the effects of cannabinoids on memory highlights their key roles in cognitive processes and further indicates that astrocytes are central active elements of high-order brain functions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 323, 26 May 2016, Pages 35-42
نویسندگان
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