کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6271084 1614753 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Astrocytic vesicles and gliotransmitters: Slowness of vesicular release and synaptobrevin2-laden vesicle nanoarchitecture
ترجمه فارسی عنوان
حامل های آستروسسیت و گیرنده های گلیوتیری: آلودگی آزادی های حین ویزا و سیناپتوبرین 2 -
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Unlike neurons, astrocytic vesicles have one third of synaptobrevin 2 (Sb2) molecules in a vesicle.
- The paucity of Sb2 in astrocytes may determine the slow secretory profile.
- Distinct mobility of glutamatergic vs. peptidergic vesicles contributes to astrocytic plasticity.

Neurotransmitters released at synapses activate neighboring astrocytes, which in turn, modulate neuronal activity by the release of diverse neuroactive substances that include classical neurotransmitters such as glutamate, GABA or ATP. Neuroactive substances are released from astrocytes through several distinct molecular mechanisms, for example, by diffusion through membrane channels, by translocation via plasmalemmal transporters or by vesicular exocytosis. Vesicular release regulated by a stimulus-mediated increase in cytosolic calcium involves soluble N-ethyl maleimide-sensitive fusion protein attachment protein receptor (SNARE)-dependent merger of the vesicle membrane with the plasmalemma. Up to 25 molecules of synaptobrevin 2 (Sb2), a SNARE complex protein, reside at a single astroglial vesicle; an individual neuronal, i.e. synaptic, vesicle contains ∼70 Sb2 molecules. It is proposed that this paucity of Sb2 molecules in astrocytic vesicles may determine the slow secretion. In the present essay we shall overview multiple aspects of vesicular architecture and types of vesicles based on their cargo and dynamics in astroglial cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 323, 26 May 2016, Pages 67-75
نویسندگان
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