کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6271272 | 1614754 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early development of synchrony in cortical activations in the human
ترجمه فارسی عنوان
توسعه زودهنگام در فعال سازی قشر در انسان
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کلمات کلیدی
MSTIHSIVHIQRASISATNeonatal EEG - EEG نوزادانPMA - LDC هاalgebraic connectivity - اتصال جبریBrain connectivity - اتصال مغزBiomarker - بیومارکرEarly development - توسعه اولیهMinimum spanning tree - حداقل درخت پوشاIntraventricular hemorrhage - خونریزی داخل وریدیPostmenstrual age - سن پس از قاعدگیinterquartile range - محدوده بین محدبBrain monitoring - نظارت بر مغز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Early intermittent cortical activity is thought to play a crucial role in the growth of neuronal network development, and large scale brain networks are known to provide the basis for higher brain functions. Yet, the early development of the large scale synchrony in cortical activations is unknown. Here, we tested the hypothesis that the early intermittent cortical activations seen in the human scalp EEG show a clear developmental course during the last trimester of pregnancy, the period of intensive growth of cortico-cortical connections. We recorded scalp EEG from altogether 22 premature infants at post-menstrual age between 30 and 44Â weeks, and the early cortical synchrony was quantified using recently introduced activation synchrony index (ASI). The developmental correlations of ASI were computed for individual EEG signals as well as anatomically and mathematically defined spatial subgroups. We report two main findings. First, we observed a robust and statistically significant increase in ASI in all cortical areas. Second, there were significant spatial gradients in the synchrony in fronto-occipital and left-to-right directions. These findings provide evidence that early cortical activity is increasingly synchronized across the neocortex. The ASI-based metrics introduced in our work allow direct translational comparison to in vivo animal models, as well as hold promise for implementation as a functional developmental biomarker in future research on human neonates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 322, 13 May 2016, Pages 298-307
Journal: Neuroscience - Volume 322, 13 May 2016, Pages 298-307
نویسندگان
N. Koolen, A. Dereymaeker, O. Räsänen, K. Jansen, J. Vervisch, V. Matic, G. Naulaers, M. De Vos, S. Van Huffel, S. Vanhatalo,