کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6271283 | 1614756 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
p38 mitogen-activated protein kinase activation in amygdala mediates κ opioid receptor agonist U50,488H-induced conditioned place aversion
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کلمات کلیدی
U50p-p38DRNVTA488H - 488 ساعتMAPK - MAPKp38 MAPK - P38 MAPKphosphate buffer - بافر فسفاتSERT - سختserotonin transporter - سروتونین حمل کنندهPhospho-p38 - فسفو -38locus coeruleus - لوکوس سیرولئوسconditioned place aversion - ناامیدی محل سکونتventral tegmental area - ناحیه تگمنتوم شکمیdorsal raphe nucleus - هسته رافهmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenκ opioid receptor - گیرنده اپیدمی κ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
κ opioid receptor agonists produce aversive effects in rodents, however the underlying mechanisms remain unclear. Activation of p38 mitogen-activated protein kinase (MAPK) has been discovered to play a critical role in the modulation of affective behaviors. The present study was undertaken to detect the possible involvement of p38 MAPK in the aversive effects induced by κ opioid receptor activation. We found that the κ opioid receptor agonist trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzenacetamide methanesulfonate salt (U50,488H) produced significant place aversion in mice as measured by the conditioned place preference procedure, accompanied with significant p38 MAPK activation in the amygdala, but not in the nucleus accumbens and hippocampus. Stereotaxic microinjection of the p38 MAPK inhibitor 4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridy-l)-1H-imidazole (SB203580) into amygdala significantly inhibited p38 MAPK activation and completely blocked the conditioned place aversion in mice. Thus, these results suggested that activation of p38 MAPK in the amygdala was required to mediate κ opioid receptor-induced aversive behavior.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 320, 21 April 2016, Pages 122-128
Journal: Neuroscience - Volume 320, 21 April 2016, Pages 122-128
نویسندگان
G.-Y. Zan, Q. Wang, Y.-J. Wang, J.-C. Chen, X. Wu, C.-H. Yang, J.-R. Chai, M. Li, Y. Liu, X.-W. Hu, X.-H. Shu, J.-G. Liu,