کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6271460 | 1614760 | 2016 | 47 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sodium salicylate reduces the level of GABAB receptors in the rat's inferior colliculus
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کلمات کلیدی
AMPKICCIRNICXγ-aminobutyric acid - اسید γ-آمینوبوتیریکImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیICD - دفیبریلاتورهای کاردیوورتر کاشتنیexternal cortex of the inferior colliculus - قشر خارجی کولیکولوس پایینdorsal cortex of the inferior colliculus - قشر پشتی کولیکولوس پایینCerebellum - مخچهCentral Nucleus of the Inferior Colliculus - هسته مرکزی کولیکولوس پایینInferior colliculus - کولیکولوس پایینGABA - گاباGABAB receptor - گیرنده GABAB
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Previous studies have indicated that sodium salicylate (SS) can cause hearing abnormalities through affecting the central auditory system. In order to understand central effects of the drug, we examined how a single intraperitoneal injection of the drug changed the level of subunits of the type-B γ-aminobutyric acid receptor (GABAB receptor) in the rat's inferior colliculus (IC). Immunohistochemical and western blotting experiments were conducted three hours following a drug injection, as previous studies indicated that a tinnitus-like behavior could be reliably induced in rats within this time period. Results revealed that both subunits of the receptor, GABABR1 and GABABR2, reduced their level over the entire area of the IC. Such a reduction was observed in both cell body and neuropil regions. In contrast, no changes were observed in other brain structures such as the cerebellum. Thus, a coincidence existed between a structure-specific reduction in the level of GABAB receptor subunits in the IC and the presence of a tinnitus-like behavior. This coincidence likely suggests that a reduction in the level of GABAB receptor subunits was involved in the generation of a tinnitus-like behavior and/or used by the nervous system to restore normal hearing following application of SS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 316, 1 March 2016, Pages 41-52
Journal: Neuroscience - Volume 316, 1 March 2016, Pages 41-52
نویسندگان
S. Butt, F. Ashraf, L.A. Porter, H. Zhang,