کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6272388 1614772 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prenatal stress induces vulnerability to nicotine addiction and alters D2 receptors' expression in the nucleus accumbens in adult rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Prenatal stress induces vulnerability to nicotine addiction and alters D2 receptors' expression in the nucleus accumbens in adult rats
چکیده انگلیسی


- Nicotine induces CPP in rats at the dose of 0.5 mg/kg.
- Prenatal stress intensifies nicotine-induced CPP in adult rats.
- Prenatal Stress increases DRD2 expression levels in the nucleus accumbens.
- DRD2 expression is downregulated in the nicotine-treated prenatally stressed rats.

Prenatal stress (PS) can induce several long-lasting behavioral and molecular abnormalities in rats. It can also be considered as a risk factor for many psychiatric diseases like schizophrenia, depression or PTSD and predispose to addiction.In this study, we investigated the effect of prenatal stress on the reinforcing properties of nicotine in the CPP paradigm. Then, we examined the mRNA expression of the D2 dopaminergic receptors using the quantitative real-time PCR technique in the nucleus accumbens (NAcc). We found that prenatally stressed rats exhibited a greater place preference for the nicotine-paired compartment than the control rats. Moreover, we observed an overexpression of the DRD2 gene in adult offspring stressed in utero and a downregulation in the PS NIC group (PS rats treated with nicotine) compared with their control counterparts (C NIC).These data suggest that maternal stress can permanently alter the offspring's addictive behavior and D2 receptors' expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 304, 24 September 2015, Pages 279-285
نویسندگان
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