کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6273020 1614792 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amiloride-sensitive sodium currents in fungiform taste cells of rats chronically exposed to nicotine
ترجمه فارسی عنوان
حساسیت آمیلوئید حساسیت سدیم در سلول های طعم دهنده قارچ موش هایی که به طور ناخوشایند در معرض نیکوتین قرار دارند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Chronic nicotine exposure affects membrane properties of rat fungiform taste cells.
- Chronic nicotine exposure reduces the amplitude of amiloride-sensitive Na+ currents.
- Chronic nicotine exposure reduces the activity of amiloride-sensitive Na+ channels.
- Chronic nicotine exposure makes taste cells less sensitive to salty stimuli.

Many studies have demonstrated that chronic exposure to nicotine, one of the main components of tobacco smoke, has profound effects on the functionality of the mammalian taste system. However, the mechanisms underlying nicotine action are poorly understood. In particular no information is available on the chronic effect of nicotine on the functioning of taste cells, the peripheral detectors which transduce food chemicals into electrical signals to the brain. To address this issue, I studied the membrane properties of rat fungiform taste cells and evaluated the effect of long-term exposure to nicotine on the amiloride-sensitive sodium currents (ASSCs). These currents are mediated by the epithelial sodium channels (ENaC) thought to be important, at least in part, in the transduction of salty stimuli. Patch-clamp recording data indicated that ASSCs in taste cells from rats chronically treated with nicotine had a reduced amplitude compared to controls. The pharmacological and biophysical analysis of ASSCs revealed that amplitude reduction was not dependent on changes in amiloride sensitivity or channel ionic permeability, but likely derived from a decrease in the activity of ENaCs. Since these channels are considered to be sodium receptors in taste cells, my results suggest that chronic exposure to nicotine hampers the capability of these cells to respond to sodium ions. This might represent a possible cellular mechanism underlying the reduced taste sensitivity to salt typically found in smokers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 284, 22 January 2015, Pages 180-191
نویسندگان
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