کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6273268 | 1614794 | 2014 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Generating bursts (and pauses) in the dopamine midbrain neurons
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کلمات کلیدی
LDTlateral dorsal tegmentumSFBrostromedial tegmental nucleusRMTgmGluRNMDAROFCSTNVTAGPCRMPFCN-methyl-d-aspartateACSIP3EGTANMDASNCG-protein coupled receptor - G-پروتئین همراه گیرندهNMDA-receptor - NMDA گیرندهNMDA receptor - NMDA گیرندهISI - آی اس آیethylene glycol tetraacetic acid - اتیلن گلیکول تتراستیک اسیدBursting - انفجارsubstantia nigra - توده سیاهsubstantia nigra pars compacta - توده سیاه پارس متراکمDopamine - دوپامینinter-spike interval - فاصله بین سنبلهPhosphoinositol - فسفوئنوزیتولorbitofrontal cortex - قشر اوربیتوفرنتالmedial prefrontal cortex - قشر غده پروسترولPPN - مالیات بر ارزش افزودهventral tegmental area - ناحیه تگمنتوم شکمیSubthalamic nucleus - هسته ی زیرهالامیکChannels - کانال هاglutamate - گلوتاماتMetabotropic glutamate receptor - گیرنده گلوتامات متابوتروپیکDynamic-clamp - گیره دینامیکی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Dopamine (DA) midbrain neurons project to several striatal and cortical target areas and are essentially involved in a puzzling variety of important brain functions such as action selection and motor performance, motivation and reward-based learning, but also working memory and cognition. These neurons act via the release of their (main) neurotransmitter, dopamine, which binds to metabotropic dopamine receptors of the D1 or D2 type on target neurons. Axonal but also dendritic dopamine release is essentially controlled by calcium-triggered exocytosis of dopamine-filled synaptic vesicles primarily driven by electrical activity of the dopamine neuron, which generates patterns of actions potentials in the somato-dendritic domain and distributes them along its axonal tree. Thus, recording the behaviorally relevant pattern of electrical activity in DA neurons and identifying the underlying biophysical mechanisms that integrate afferent synaptic inputs and intrinsic excitability constitute a crucial element for defining the physiological roles of the midbrain DA system. Electrical activity of midbrain DA neurons in vivo is characterized by tonic background activity in a narrow frequency range (ca. 1-8Â Hz) interrupted by either transient (i.e. phasic, <500Â ms) sequences of high-frequency firing (>15Â Hz), so called “bursts”, or transient pauses of electrical activity, where DA neurons generate no action potentials. This review focuses on the properties of these phasic activity changes in midbrain DA neurons. It updates recent progress on the expanding behavioral contexts, associated with phasic electrical activity in DA neurons beyond the classical (canonical) reward prediction error model. The review also highlights recently defined contributions of synaptic inputs for burst and pause generation and the roles of distinct postsynaptic ion channels in midbrain DA neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 282, 12 December 2014, Pages 109-121
Journal: Neuroscience - Volume 282, 12 December 2014, Pages 109-121
نویسندگان
C.A. Paladini, J. Roeper,