کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6273293 1614794 2014 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewPrefrontal dopamine in associative learning and memory
ترجمه فارسی عنوان
بررسی دوپامین در یادگیری و حافظه انجمنی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Prefrontal D1R and D2R modulate associative learning and cognitive flexibility.
- Prefrontal D1R and D2R modulate learning-related neural information.
- Blocking D1R increases alpha and beta oscillations and neuron excitability.
- Blocking D2R increases alpha oscillations and reduces neuron excitability.
- Prefrontal D1R and D2R modulate learning in a cooperative manner.

Learning to associate specific objects or actions with rewards and remembering the associations are everyday tasks crucial for our flexible adaptation to the environment. These higher-order cognitive processes depend on the prefrontal cortex (PFC) and frontostriatal circuits that connect areas in the frontal lobe with the striatum in the basal ganglia. Both structures are densely innervated by dopamine (DA) afferents that originate in the midbrain. Although the activity of DA neurons is thought to be important for learning, the exact role of DA transmission in frontostriatal circuits during learning-related tasks is still unresolved. Moreover, the neural substrates of this modulation are poorly understood. Here, we review our recent work in monkeys utilizing local pharmacology of DA agents in the PFC to investigate the cellular mechanisms of DA modulation of associative learning and memory. We show that blocking both D1 and D2 receptors in the lateral PFC impairs learning of new stimulus-response associations and cognitive flexibility, but not the memory of highly familiar associations. In addition, D2 receptors may also contribute to motivation. The learning deficits correlated with reductions of neural information about the associations in PFC neurons, alterations in global excitability and spike synchronization, and exaggerated alpha and beta neural oscillations. Our findings provide new insights into how DA transmission modulates associative learning and memory processes in frontostriatal systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 282, 12 December 2014, Pages 217-229
نویسندگان
, , ,