β-Caryophyllene protects the C6 glioma cells against glutamate-induced excitotoxicity through the Nrf2 pathway

- β-Caryophyllene (BCP) prevented astrocytes from glutamate-induced cytotoxicity.
- BCP inhibits ROS production and mitochondrial dysfunction.
- BCP upregulates the glutathione antioxidant system through the Nrf2 pathway.
- Antioxidant effects of BCP are dependent of CB2R activation.