کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6274436 1614826 2013 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuroscience Forefront ReviewNeural processing of itch
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Neuroscience Forefront ReviewNeural processing of itch
چکیده انگلیسی


- There are histamine-dependent and -independent types of itch.
- Molecular detectors of pruritogens include Mrgprs, PARs, and many others.
- Spinal transmitters include gastrin releasing peptide and natriuretic polypeptide B.
- Pruritogen-sensitive sensory neurons usually also respond to pain-producing stimuli.
- Pruritogen-responsive sensory neurons connect to an itch-specific central pathway.

While considerable effort has been made to investigate the neural mechanisms of pain, much less effort has been devoted to itch, at least until recently. However, itch is now gaining increasing recognition as a widespread and costly medical and socioeconomic issue. This is accompanied by increasing interest in the underlying neural mechanisms of itch, which has become a vibrant and rapidly-advancing field of research. The goal of the present forefront review is to describe the recent progress that has been made in our understanding of itch mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 697-714
نویسندگان
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