کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6274489 | 1614826 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuroprotective efficacy of subcutaneous insulin-like growth factor-I administration in normotensive and hypertensive rats with an ischemic stroke
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کلمات کلیدی
PBSTNFNIHSHRsET-1MCAONDSIGF-IGFAPendothelin-1 - اندوتلین-1middle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیBrain ischemia - ایسکمی مغزinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینstandard error of mean - خطای استاندارد میانگینInsulin-like growth factor-I - عامل رشد انسولین مانند Itumor necrosis factor - فاکتور نکروز تومورHypertension - فشار خون بالاPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیApes - مردابNational Institute of Health - موسسه ملی بهداشتSpontaneously hypertensive rats - موش های خودبخود فشار خون بالاNeurological deficit score - نمره نارسایی عصبیNeuroglia - نورلوژیGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایال
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
The aim of this study was to test the insulin-like growth factor-I (IGF-I) as a neuroprotective agent in a rat model for ischemic stroke and to compare its neuroprotective effects in conscious normotensive and spontaneously hypertensive rats. The effects of subcutaneous IGF-I injection were investigated in both rat strains using the endothelin-1 rat model for ischemic stroke. Motor-sensory functions were measured using the Neurological Deficit Score. Infarct size was assessed by Cresyl Violet staining. Subcutaneous administration of IGF-I resulted in significantly reduced infarct volumes and an increase in motor-sensory functions in normotensive rats. In these rats, IGF-I did not modulate blood flow in the striatum and had no effect on the activation of astrocytes as assessed by GFAP staining. In hypertensive rats, the protective effects of IGF-I were smaller and not always significant. Furthermore, IGF-I significantly reduced microglial activation in the cortex of hypertensive rats, but not in normotensive rats. More detailed studies are required to find out whether the reduction by IGF-I of microglial activation contributes to an impairment IGF-I treatment efficacy. Indeed, we have shown before that microglia in hypertensive rats have different properties compared to those in control rats, as they exhibit a reduced responsiveness to ischemic stroke and lipopolysaccharide.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 253-262
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 253-262
نویسندگان
D. De Geyter, W. Stoop, S. Sarre, J. De Keyser, R. Kooijman,