Surgical incision induces phosphorylation of AMPA receptor GluR1 subunits at Serine-831 sites and GluR1 trafficking in spinal cord dorsal horn via a protein kinase Cγ-dependent mechanism

► Surgical incision enhanced the membrane translocation level of PKCγ in dorsal horns. ► Surgical incision induced the trafficking of GluR1 into neuronal plasmic membrane. ► Intrathecal PKCγ siRNA inhibited the phosphorylation of GluR1 at Serine-831 site. ► Intrathecal PKCγ siRNA inhibited GluR1 membrane trafficking. ► Intrathecal PKCγ siRNA blunted the pain hypersensitivity.