GABAB receptors as a common target for hypothermia and spike and wave seizures: Intersecting mechanisms of thermoregulation and absence epilepsy

► PTZ and GHB induced both absence seizures and mild hypothermia. ► Drug-free deep cooling induced frequent SWD and accompanied behavioral correlates. ► A selective GABAB antagonists prevented both the hypothermia and SWD. ► GABAB receptors connect the thermoregulation and absence epileptogenecity. ► The role of the preoptic hypothalamic nuclei in absence epilepsy has to be reconsidered.