Unique features of extracellular matrix in the mouse medial nucleus of trapezoid body - Implications for physiological functions

► We studied the ECM of PNs in the MNTB of the auditory system in detail. ► Every MNTB neuron is surrounded by a remarkably prominent PN. ► We discovered a new distinct structural phenotype of PNs in MNTB. ► The Proteoglycans aggrecan and brevican show unique/differing spatial positions. ► Our data support the hypothesis that PNs affect physiological functions of neurons.