Role of sensory input distribution and intrinsic connectivity in lateral amygdala during auditory fear conditioning: A computational study

► New firing rate model with full spike-frequency adaptation and non-zero rheobase. ► Calcium-based learning rule implementation for networks of firing rate neurons. ► Framework to study possible tone-shock distributions in LA for learning fear. ► Tone-interneuron connectivity should be >60% to match experimental data. ► Model shows how impairment in inhibitory LTP might cause fear generalization.