Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat

► Rotenone-induced behavioral deficits confirmed with SDS-PAGE and IF studies. ► Rotenone-induced parkinsonism elicits lower parkin and DJ1 expression. ► Enhanced level of caspase 3, 9, and Hsp60 in rotenone-treated PD model. ► Rotenone-induced neuronal damages have been seen in silver and TH staining. ► HSP and Ubiquitin E3 ligase can reverse the negative effect of rotenone-induced PD.