Migration and fate of therapeutic stem cells in different brain disease models

▶A number of receptor/ligand pairs have been implicated in the migration of transplanted stem cells toward regions of pathology in the mammalian brain. ▶Efforts at guiding the migration and differentiation of therapeutic stem cells into terminal cell types are ongoing. ▶Imaging stem cells in real time in vivo provides vital clues about their fate in vivo. ▶Extensive preclinical studies are crucial to ultimately test the potential of therapeutic stem cells in human settings.