5-hydroxytryptamine 2C receptors in the dorsal striatum mediate stress-induced interference with negatively reinforced instrumental escape behavior

▶Prior uncontrollable stress sensitizes extracellular 5-HT in the striatum. ▶5-HT2CR in DS are necessary for stress-induced instrumental learning deficits. ▶5-HT2CR activation in DS interferes with instrumental escape learning. ▶5-HT2CR activation in BLA enhances conditioned fear. ▶5-HT2CR in BLA contributes to stress-induced instrumental learning deficits.