Glutamate and nicotinic receptor interactions in working memory: importance for the cognitive impairment of schizophrenia

▶NMDA inhibition reproduces cellular and cognitive impairments of schizophrenia. ▶α7 AChR agonists reduce such impairments. ▶Parvalbumin interneurons generate gamma oscillations. ▶They are severely affected in schizophrenia. ▶Parvalbumin interneurons could play a crucial role in working memory.