Cytoarchitectural disruption of the superior colliculus and an enlarged acoustic startle response in the Tuba1a mutant mouse

▶We investigate the superior colliculus and behaviour of a mouse model of lissencephaly. ▶We find that there is abnormal lamination and impairment in neuronal migration. ▶This is accompanied by a massive increase in postnatal neuronal cell death. ▶This is associated with an exaggerated acoustic startle response. ▶This study aids our understanding of disease mechanisms.