Changes in postnatal norepinephrine alter alpha-2 adrenergic receptor development

▶Neonatal noradrenergic lesions with DSP4 have little effect on A2AR development. ▶The developmental response of A2AR to DSP4 is different from adults. ▶Increasing NE with MAM during development increases A2AR expression into adulthood. ▶The developmental change after increased NE is opposite what is expected in adults. ▶NE regulates A2AR development and has long term effects on A2AR function.