کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6276325 1614886 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin
چکیده انگلیسی
▶We produced the first knockout mouse of Dcdc2. ▶We find no evidence of neuronal migration disruption in the Dcdc2 mutants. ▶Dcx RNAi causes a more severe migration deficit in the Dcdc2 mutants. ▶Dcx RNAi cause a more severe effect on the growth and elaboration of dendrites in the Dcdc2 mutants. ▶Dcdc2 on its own is not required for neuronal migration in the neocortex, but does render the neocortex more susceptible to migration disruptions caused by Dcx RNAi.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 190, 5 September 2011, Pages 398-408
نویسندگان
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