Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin

▶We produced the first knockout mouse of Dcdc2. ▶We find no evidence of neuronal migration disruption in the Dcdc2 mutants. ▶Dcx RNAi causes a more severe migration deficit in the Dcdc2 mutants. ▶Dcx RNAi cause a more severe effect on the growth and elaboration of dendrites in the Dcdc2 mutants. ▶Dcdc2 on its own is not required for neuronal migration in the neocortex, but does render the neocortex more susceptible to migration disruptions caused by Dcx RNAi.