Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury

▶Microglia express TLR2, IL-23 and IL-17 in response to cerebral IR. ▶OGDR induces expression of TLR2, IL-23 and IL-17 in microglia in vitro. ▶OGDR microglia enhance neuronal apoptosis. ▶TLR2/IL-23/IL-17 pathways in microglia at least partially participate neuronal damage after cerebral IR.