کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277177 | 1295749 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low-frequency stimulation of the hippocampus following fear extinction impairs both restoration of rapid eye movement sleep and retrieval of extinction memory
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کلمات کلیدی
PLSDHippocampal stimulationFear returnLFSSWSREMextinction memorypost-traumatic stress disorder - اختلال استرس پس از ضربهPTSD - اختلال استرسی پس از ضایعه روانیElectroencephalogram - الکتروانسفالوگرافیelectromyogram - الکترومیوگرافیEMG - الکترومیوگرافیlow-frequency stimulation - تحریک با فرکانس پایینFear conditioning - تهدید ترسrapid eye movement - حرکت سریع چشمprotected least significant difference - حفاظت شده حداقل تفاوت قابل توجهیslow-wave sleep - خواب آهستهREM sleep - خواب همراه با حرکات سریع چشمunconditioned stimulus - محرک بی قید و شرطconditioned stimulus - محرک شرطیRats - موش صحراییEEG - نوار مغزی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Low-frequency stimulation of the hippocampus following fear extinction impairs both restoration of rapid eye movement sleep and retrieval of extinction memory Low-frequency stimulation of the hippocampus following fear extinction impairs both restoration of rapid eye movement sleep and retrieval of extinction memory](/preview/png/6277177.png)
چکیده انگلیسی
Post-learning rapid eye movement (REM) sleep deprivation has often been shown to impair hippocampal functioning, which results in deficit in retrieval of some types of memory. However, it remains to be determined whether post-learning alteration of hippocampal functioning affects, in turn, REM sleep. Recent studies have shown that both post-extinction REM sleep deprivation and post-extinction application of hippocampal low-frequency stimulation (LFS) impair memory of fear extinction, indicating possible bidirectional interactions between hippocampal functioning and REM sleep. To analyze the potential effect of post-extinction alteration of hippocampal functioning on REM sleep, rats were implanted with stimulating electrodes in the dorsal hippocampus for post-extinction LFS. Sleep was recorded before (two sessions, 1 day apart) and after conditioning (five tone and eyelid-shock pairings), and following extinction training (25 tone-alone presentations) for 6 h per session. Fear conditioning reduced time spent in REM sleep, which was restored with fear extinction. Hippocampal LFS, applied immediately following extinction training, abolished the restorative effect of fear extinction on REM sleep and impaired extinction retrieval. These data extend previous findings and suggest bidirectional interactions between hippocampal functioning and REM sleep for successful extinction retrieval.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 170, Issue 1, 29 September 2010, Pages 92-98
Journal: Neuroscience - Volume 170, Issue 1, 29 September 2010, Pages 92-98
نویسندگان
O. Deschaux, A. Thevenet, G. Spennato, C. Arnaud, J.L. Moreau, R. Garcia,