کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277435 | 1295757 | 2010 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Short- but not long-lasting treadmill running reduces allodynia and improves functional recovery after peripheral nerve injury
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کلمات کلیدی
GFAPtoe spreadcdc2vHCGAP-43CCISSIDHCchronic constriction injury - آسیب زدگی مزمنImmunoreactivity - ایمنی فعالImmunofluorescence - ایمونوفلورسانسNerve regeneration - بازسازی عصبNeuropathic pain - درد نوروپاتیکgrowth associated protein 43 - رشد پروتئینی مرتبط با آن 43glial cells - سلول های گلیالSpinal cord - طناب نخاعیSciatic nerve - عصب سیاتیکMice - موشNOT - نهsed - وGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایال
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We analyzed the effects of different treadmill running protocols on the functional recovery after chronic constriction injury (CCI) of the sciatic nerve in mice. We found that a treadmill protocol of short-lasting running (1 h/d for 5 days after CCI) reduced the neuropathy-induced mechanical allodynia and normalized the weight bearing and the sciatic static index of the injured hindpaw. At difference, a treadmill protocol of long-lasting running (1 h/d for more than 5 days after CCI) was unfavorable both for allodynia and for functional recovery. Behavioral results were correlated with immunofluorescence assays of microglia and astrocytes activation in L4/L5 lumbar spinal cord sections. We found a differential pattern of activation characterized by: (i) reduced microglia expression, after both short- and long-lasting treadmill running; (ii) reduced astrocytes expression after short-lasting treadmill running; and, (iii) persistence of astrocytes expression after long-lasting treadmill running. Finally, in sections of injured sciatic nerves, we analyzed the expression of Cdc2 and GAP-43 proteins that are both up-regulated during peripheral regenerative processes. Compared to mice subjected to long-lasting treadmill running, mice subjected to short-lasting treadmill running showed an acceleration of the regenerative processes at the injured sciatic nerve. Our data demonstrate that short-lasting treadmill running, by reducing the neuropathic pain symptoms and facilitating the regenerative processes of the injured nerve, have beneficial rehabilitative effects on the functional recovery after peripheral nerve injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 168, Issue 1, 16 June 2010, Pages 273-287
Journal: Neuroscience - Volume 168, Issue 1, 16 June 2010, Pages 273-287
نویسندگان
S. Cobianchi, S. Marinelli, F. Florenzano, F. Pavone, S. Luvisetto,