کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277739 | 1295771 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduced caudate nuclei volumes in patients with congenital central hypoventilation syndrome
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کلمات کلیدی
Three-dimensionalICCCCHSPPTMANCOVAFOVPedunculopontine tegmentum - Pedunculopontine TEGMENTUMStriatum - استریاتومMultivariate analysis of covariance - تجزیه و تحلیل چند متغیره کوواریانسMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیCongenital central hypoventilation syndrome - سندرم hypoventilation مرکزی مادرزادیCognition - شناختintraclass correlation coefficient - ضریب همبستگی داخل کلاسیbasal ganglia - عقدههای قاعدهایBrain - مغزfield-of-view - میدان دیدHypoxia - هیپوکسی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Congenital central hypoventilation syndrome (CCHS) children show cognitive and affective deficits, in addition to state-specific loss of respiratory drive. The caudate nuclei serve motor, cognitive, and affective roles, and show structural deficits in CCHS patients, based on gross voxel-based analytic procedures. However, the magnitude and regional sites of caudate injury in CCHS are unclear. We assessed global caudate nuclei volumes with manual volumetric procedures, and regional volume differences with three-dimensional surface morphometry in 14 CCHS (mean age±SD: 15.1±2.3 years; 8 male) and 31 control children (15.1±2.4 years; 17 male) using brain magnetic resonance imaging (MRI). Two high-resolution T1-weighted image series were collected using a 3.0 Tesla MRI scanner; images were averaged and reoriented (rigid-body transformation) to common space. Both left and right caudate nuclei were outlined in the reoriented images, and global volumes calculated; surface models were derived from manually-outlined caudate structures. Global caudate nuclei volume differences between groups were evaluated using a multivariate analysis of covariance (covariates: age, gender, and total intracranial volume). Both left and right caudate nuclei volumes were significantly reduced in CCHS over control subjects (left, 4293.45±549.05 vs. 4626.87±593.41 mm3, P<0.006; right, 4376.29±565.42 vs. 4747.81±578.13 mm3, P<0.004). Regional deficits in CCHS caudate volume appeared bilaterally, in the rostral head, ventrolateral mid, and caudal body. Damaged caudate nuclei may contribute to CCHS neuropsychological and motor deficits; hypoxic processes, or maldevelopment in the condition may underlie the injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 163, Issue 4, 10 November 2009, Pages 1373-1379
Journal: Neuroscience - Volume 163, Issue 4, 10 November 2009, Pages 1373-1379
نویسندگان
R. Kumar, R. Ahdout, P.M. Macey, M.A. Woo, C. Avedissian, P.M. Thompson, R.M. Harper,