کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277883 | 1295777 | 2009 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mouse plasmacytoma-expressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness
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کلمات کلیدی
CWMPCPATphPet-1MWMPPI5,7-DHT - 5،7-DHTp-Chloroamphetamine - p-کلروامفتامینp-Chlorophenylalanine - p-کلروفنیل آلانینPCA - PCAmarble burying - دفن سنگ مرمرpostnatal day - روز پس از زایمانSERT - سختSerotonin (5-HT) - سروتونین (5-HT)serotonin transporter - سروتونین حمل کنندهLocomotor activity - فعالیت locomotorMorris water maze - ماز آب آب موریسMethamphetamine - متیل آمفتامینPrepulse inhibition - مهار پیش قاعدگیwild-type - نوع وحشیtryptophan hydroxylase - هیدروکسیلاز تریپتوفانStartle - وحشت زده شدنCincinnati water maze - گنجینه آب سینسیناتی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Serotonin (5-HT) is involved in many developmental processes and influences behaviors including anxiety, aggression, and cognition. Disruption of the serotonergic system has been implicated in human disorders including autism, depression, schizophrenia, and ADHD. Although pharmacological, neurotoxin, and dietary manipulation of 5-HT and tryptophan hydroxylase has added to our understanding of the serotonergic system, the results are complicated by multiple factors. A newly identified ETS domain transcription factor, Pet-1, has direct control of major aspects of 5-HT neuronal development. Pet-1 is the only known factor that is restricted in the brain to 5-HT neurons during development and adulthood and exerts dominant control over 5-HT neuronal phenotype. Disruption of Pet-1 produces an â¼80% loss of 5-HT neurons and content and results in increased aggression in male Pet-1â/â mice [Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B, Silver J, Weeber EJ, Sweatt JD, Deneris ES (2003) Neuron 37:233-247]. We hypothesized that Pet-1â/â mice would also exhibit changes in anxiety and cognition. Pet-1â/â mice were hypoactive which may have affected the observed lack of anxious behavior in the elevated zero maze and light-dark test. Pet-1â/â mice, however, were more defensive during marble burying and showed acoustic startle hyper-reactivity. No deficits in spatial, egocentric, or novel object recognition learning were found in Pet-1â/â mice. These findings were unexpected given that 5-HT depleting drugs given to adult or developing animals result in learning deficits [Mazer C, Muneyyirci J, Taheny K, Raio N, Borella A, Whitaker-Azmitia P (1997) Brain Res 760:68-73; Morford LL, Inman-Wood SL, Gudelsky GA, Williams MT, Vorhees CV (2002) Eur J Neurosci 16:491-500; Vorhees CV, Schaefer TL, Williams MT (2007) Synapse 61:488-499]. Lack of differences may be the result of compensatory mechanisms in reaction to a constitutive knock out of Pet-1 or 5-HT may not be as important in learning and memory as previously suspected.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 164, Issue 4, 29 December 2009, Pages 1431-1443
Journal: Neuroscience - Volume 164, Issue 4, 29 December 2009, Pages 1431-1443
نویسندگان
T.L. Schaefer, C.V. Vorhees, M.T. Williams,